{"id":31412,"date":"2022-10-22T10:36:25","date_gmt":"2022-10-22T08:36:25","guid":{"rendered":"https:\/\/karmaka.de\/?p=31412"},"modified":"2022-10-22T10:53:21","modified_gmt":"2022-10-22T08:53:21","slug":"hydrogen-drives-part-of-the-reverse-krebs-cycle-under-metal-or-meteorite-catalysis","status":"publish","type":"post","link":"https:\/\/karmaka.de\/?p=31412","title":{"rendered":"Hydrogen Drives Part of the Reverse Krebs Cycle under Metal or Meteorite Catalysis<span class=\"badge-status\" style=\"background:#787878\">OPEN ACCESS<\/span>&nbsp;"},"content":{"rendered":"\n<p>Sophia A. Rauscher, Joseph Moran<\/p>\n\n\n\n<p>Angewandte Chemie International Edition<br>First published: 17 October 2022<\/p>\n\n\n\n<p><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.202212932\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>LINK (OPEN ACCESS)<\/strong><\/a><br><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/anie.202212932\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>PDF (OPEN ACCESS)<\/strong><\/a><\/p>\n\n\n\n<p class=\"justify-text\">&#8220;Hydrogen (H2) is a geological source of reducing electrons that is thought to have powered the metabolism of the last universal common ancestor to all extant life and that is still metabolized by various modern organisms. It has been suggested that H2 drove a geochemical analogue of some or all of the reverse Krebs cycle at the origin of the metabolic network, catalyzed by metals, but this has yet to be demonstrated experimentally. Here, we show that three consecutive steps of the reverse Krebs cycle, converting oxaloacetate to succinate, can be driven without enzymes and in one-pot by H2 as the reducing agent under mild conditions compatible with biological chemistry. Low catalytic amounts of nickel (10\u221220 mol%) or platinum group metals (0.1\u22121 mol%) or even small amounts of ground meteorites are found to promote the reductive chemistry at temperatures between 5 and 60 \u00b0C and over a wide pH range, including pH 7. These results lend additional support to the hypothesis that geologically produced hydrogen and metal catalysts could have initiated early biochemical networks.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sophia A. Rauscher, Joseph Moran Angewandte Chemie International EditionFirst published: 17 October 2022 LINK (OPEN ACCESS)PDF (OPEN ACCESS) &#8220;Hydrogen (H2) is a geological source of reducing electrons that is thought to have powered the metabolism&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[112,214,576],"tags":[377,862,192,1874,1135,2413,5467,2867,804],"_links":{"self":[{"href":"https:\/\/karmaka.de\/index.php?rest_route=\/wp\/v2\/posts\/31412"}],"collection":[{"href":"https:\/\/karmaka.de\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/karmaka.de\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/karmaka.de\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/karmaka.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=31412"}],"version-history":[{"count":2,"href":"https:\/\/karmaka.de\/index.php?rest_route=\/wp\/v2\/posts\/31412\/revisions"}],"predecessor-version":[{"id":31414,"href":"https:\/\/karmaka.de\/index.php?rest_route=\/wp\/v2\/posts\/31412\/revisions\/31414"}],"wp:attachment":[{"href":"https:\/\/karmaka.de\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=31412"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/karmaka.de\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=31412"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/karmaka.de\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=31412"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}